OSTEOGENIC SARCOMA

OSTEOGENIC SARCOMA

INTRODUCTION:

Osteogenic sarcoma is the most common malignant tumour of bone. It is derived from osteoblasts in which tumour cells contain high level of alkaline phosphatase.

ETIOLOGY:

i. Following radiation therapy

ii. Traumatic irritation

iii. Fibro-osseous diseases like fibrous dysplasia and Paget’s disease

iv. Genetic mutation

v. Viral causes

CLINICAL FEATURES:

l. Common in males in age group of 30’s.

2. Common in long bones like femur and tibia and in jaw bones.

3. Grows rapidly and shows early metastasis via blood stream.

4. Signs of exophthalmos, blindness, nasal obstruction and epistaxis.

5. Oral manifestations are rare, maxilla and mandible are equally affected.

7. Affected tooth is displaced or loose with swelling.

8. There may be trismus and haemorrhage.

RADIOLOGICAL FEATURE:

l. Radiographic appearance is variable. It may develop into frankly osteolytic stage, mixed stage and entirely osteoblastic; mixed stage shows honey comb appearance.

2. Osteogenic stage shows sunray appearance, Codman’s triangle and onion peel appearance.

DIFFERENTIAL DIAGNOSIS:

- Carcinoma

- Chondrosarcoma

- Fibrous dysplasia

- Osteomyelitis.

TREATMENT:

Radical resection with amputation of bone.